Where the evidence stands
Retrospective feasibility demonstrated on a US adult clinical cohort. Independent external validation is in progress and is not yet complete.
No performance figures appear on this site until a public preprint or peer-reviewed paper is available. When one is, it will be linked here.
Inputs & Population
What the model reads, and who it is for
Inputs
Values already present in a routine adult workup — standard blood work, vitals and basic history, drawn and recorded as part of ordinary care.
Intended population
The primary workflow is designed for adults (18+) on a routine adult panel. It is not designed for pediatric use. Confirmatory kidney testing follows a flag; every clinical decision remains the provider's.
Patent-pending technology. Provisional patent filed March 2026.
Study Ledger
Every claim carries the stage it has actually reached
Demonstrated, in progress, designed, or still a hypothesis — the same maturity vocabulary used across the site.
Retrospective feasibility
DemonstratedFeasibility demonstrated retrospectively on a US adult clinical cohort: the model produces risk stratification from routine-panel inputs. Retrospective results do not guarantee prospective clinical performance.
Independent external validation
In progressExternal validation on independent cohort data is in progress and is not yet complete. Performance results will be published when a public preprint or paper is available — none are stated before then.
STRATA — first sponsor retrospective study
Study designedA governed, model-to-data retrospective study design: whether model-assisted review of routine panels would surface candidates for confirmatory kidney evaluation that a standard site query misses, and at what review cost. Written as design; no results exist to report.
CADENCE — progression validation design
Study designedA validation study design for CKD progression questions — serial routine panels read as a longitudinal trajectory. A separate model and a separate evidence path from the prevalence work; it would need its own validation before any claim is made.
Prospective clinical evaluation
Research hypothesisProspective evaluation in live clinical workflows is the stage after external validation completes. Its design will be published alongside the pilots that carry it.
Primary Sources
Clinical and methodological references
The clinical claims this site makes trace to primary literature and guidelines.
- 1KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of CKD
- 2CDC — Chronic Kidney Disease data & research (prevalence and awareness)
- 3USRDS Annual Data Report — CKD and ESRD costs and populations
- 4FDA guidance — Clinical Decision Support Software (21st Century Cures Act)
- 5HL7 FHIR R4 specification
- 6ISN Global Kidney Health Atlas (2023), International Society of Nephrology
- 7ISN/WHO Kidney Health Resolution Implementation Guide (2050 projection)
- 8Internal feasibility analysis on a US adult clinical cohort (internal; not a public source — manuscript in preparation)